Question:
BlessedBy2 wrote: > J Child Neurol 1999 Jun;14(6):388-94 > Familial clustering of autoimmune disorders and evaluation of > medical risk factors in autism.
Interresting ! BTW, sorry for my constantly change in name. I willl stick to ‘The cabbage’ 
(You don’t want to ask me why, unless you are bored and prepared for a volumious reply). I wonder if there are any statistics regarding blood-type and autoimmune disorders. The immune system in type O differs from the other blood types. Body cells in persons with blood type A,B and AB have ‘identification tags’ used to separate body cells from external cells. (Freely after Peter J. D’Adamos book eat right for your type.) The old O system must use other means of identification, and perhaps this is what happens when the immune defence attacks the body cells which has similar structures as troublesome ‘intruders’. -martinf.
Response:
J Child Neurol 1999 Jun;14(6):388-94 Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN Johns Hopkins Hospital, Division of Pediatric Neurology, Baltimore, MD 21212, USA. Autism is an age-dependent neurologic disorder that is often associated with autoimmune disorders in the patients’ relatives. To evaluate the frequency of autoimmune disorders, as well as various prenatal and postnatal events in autism, we surveyed the families of 61 autistic patients and 46 healthy controls using questionnaires. The mean number of autoimmune disorders was greater in families with autism; 46% had two or more members with autoimmune disorders. As the number of family members with autoimmune disorders increased from one to three, the risk of autism was greater, with an odds ratio that increased from 1.9 to 5.5, respectively. In mothers and first-degree relatives of autistic children, there were more autoimmune disorders (16% and 21%) as compared to controls (2% and 4%), with odds ratios of 8.8 and 6.0, respectively. The most common autoimmune disorders in both groups were type 1 diabetes, adult rheumatoid arthritis, hypothyroidism, and systemic lupus erythematosus. Forty-six percent of the autism group reported having relatives with rheumatoid diseases, as compared to 26% of the controls. Prenatal maternal urinary tract, upper respiratory, and vaginal infections; asphyxia; prematurity, and seizures were more common in the autistic group, although the differences were not significant. Thirty-nine percent of the controls, but only 11% of the autistic, group, reported allergies. An increased number of autoimmune disorders suggests that in some families with autism, immune dysfunction could interact with various environmental factors to play a role in autism pathogenesis.
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