Question:
Successful treatment with anti-CD20 monoclonal antibody (rituximab) of life-threatening refractory systemic lupus erythematosus with renal and central nervous system involvement. Lupus. 2003;12(10):798-800. Saito K, Nawata M, Nakayamada S, Tokunaga M, Tsukada J, Tanaka Y. Bruce
Response:
However, I read that because in some ’study patients’, they observed high levels of antibodies against rituximab (human anti chimeric antibodies -*HACA) they think that for future treatments the monoclonal antibody (rituximab) will probably be used in combination with other immunosuppressive treatments. Where did you get your info Bruce? Hugs from Shelagh http://members.shaw.ca/tiderington. – Hide quoted text — Show quoted text -"blader" <bla…@chartermi.net> wrote in message > Successful treatment with anti-CD20 monoclonal antibody (rituximab) of > life-threatening refractory systemic lupus erythematosus with renal and > central nervous system involvement. > Lupus. 2003;12(10):798-800. > Saito K, Nawata M, Nakayamada S, Tokunaga M, Tsukada J, Tanaka Y. > Bruce
Response:
Shelagh wrote: > However, I read that because in some ’study patients’, they > observed high levels of antibodies against rituximab (human anti > chimeric antibodies -*HACA) > they think that for future treatments the monoclonal antibody > (rituximab) will probably be used in combination with other > immunosuppressive treatments.
It’s in Phase I (usually toxicity) trials http://www.clinicaltrials.gov/ct/show/NCT00036491?order=6 J
Response:
"Shelagh" <tidering…@shaw.ca> skrev i meddelandet news:3B5sc.572806$Ig.343946@pd7tw2no… > However, I read that because in some ’study patients’, they > observed high levels of antibodies against rituximab (human anti > chimeric antibodies -*HACA) > they think that for future treatments the monoclonal antibody > (rituximab) will probably be used in combination with other > immunosuppressive treatments.
Those HACA antibodies can be a major problem, since they can both cancel the treatment effects and cause severe allergic reactions. Remicade (infliximab), which I have been on, is also a monoclonal antibody with non-human regions and I developed HACA antibodies against the mouse part in it. Anyway, concomitant use of Imuran or Methotrexate reduces the formation of antibodies in Remicade patients (although it didn’t in me), so it makes sense that same would apply to Rituximab. Nnia
Response:
To the question, "where did I get my information?", from a search of the Medline data base using either http://gateway.nlm.nih.gov/gw/Cmd or http://www.ncbi.nlm.nih.gov/entrez/query.fcgi Bruce
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