Question:
In article <356A3324.4E614…@ix.netcom.com>, D. Williams <david…@ix.netcom.com> writes – Hide quoted text — Show quoted text ->I had to import it from Greece and Italy. I have extra for sell but >please don’t attack me for spam or whatever. All the proceeds from the >sell of licorice is donated to charity. >I have put togeather a web site for licorice and chronic fatigue >syndrome at: >http://www.serve.com/licorice >The site is designed to help people with chronic fatigue but much of the >information will likely apply to lupus. >There are no quarantees and I have no experience in helping people with >lupus, but the herb is cheap and worth a try since it has so many other >benefits, including cancer prevention. Four months trial supply would >cost about $10 per month and I would volunteer to help a lupus patient >get started for no charge provided the person agreed to help others if >they got good response with licorice. >Dave Williams >Daniel Richards wrote: >> Where do you find this purer form of licorice?
To MS ers who get fatigue, (probably all of us). I spotted this on the LUPUS NG (I browse it for my sister who has Lupus) and don’t remember ever seeing Licorice discussed as an aid to coping with fatigue. Any one have any info? — Barbara Barton
Response:
On Wed, 27 May 1998 15:24:28 -0500, "D. Williams" – Hide quoted text — Show quoted text -<david…@ix.netcom.com> wrote: >KCD wrote: >> On Fri, 22 May 1998 10:37:30 -0500, "D. Williams" >> <david…@ix.netcom.com> wrote: >> >Licorice extract also is as effective as codiene in relieving a cough. It >> >kills virus, bacteria and mycoplasma. It is also a potent cancer preventive >> >agent. >> >D. Williams >> Okay…. trick question…. >> Where might one find licorice extract, Dave? >> kc >Okay…. trick answer….. >I don’t know!
oh… man… well… bummer… Seriously though… you really don’t know? I appreciate all your expertise on this topic. Now I’m wondering if I sounded like I was being a smart*ss. I really wasn’t. Just have a poor sense of humor when I’m in pain… thanks anyway. kc
Response:
KCD wrote: > snip….. > I appreciate all your expertise on this topic. Now I’m wondering if I > sounded like I was being a smart*ss. I really wasn’t. Just have a > poor sense of humor when I’m in pain…
Now I remember the place you can get licorice extract. You’ll find info on licorice and chronic fatigue syndrome at: http://www.serve.com/licorice In my opinion, most everything that applies to CFS would also apply to lupus. These two illness seem to be kissing cousins. I suspect that a strong connect between the two will turn out to be poor red cell health (low red cell counts, low hemoglobin, and etc). Hemoglobin scavenges nitric oxide so if you have a borderline-low count in red cells or hemoglobin, less nitirc oxide will be remove from the system and the more damage you will suffer as a result of hyperimmunity. If you also have borderline low cortisol levels, you are in for a serious state of chronic disease because low cortisol levels can down-regulated the process whereby the body manufactures red cells. This sets the stage for a "vicious circle." Licorice extract, which inhibits the enzyme that deactivates cortisol, just might be a super effective herb when combined with low-dose hydrocortisone for treating many autoimmune diseases, including lupus. The maximum inhibition of the enzyme that inhibits cortisol (11-beta hydroxysteriod dehydrogenase) occurs about 3 hours after taking 2-5 grams of licorice extract on an empty stomach. If <2.5 mg of hydrocortisone (cortisol) is taken 3 hours later to correspond with the maximum inhibition of this enzyme, then the dose of hydrocortisone remains bioactive much longer and has about 6-10 times the activity than it would have if the cortisol inhibiting enzyme were not blocked by licorice extract. Hydrocortiosone 2.5 mg potentiated 6 times by reducing the enzyne that normally inhibits cortisol equals a dose of ~15 mg of hydrocortisone. Since the body normally produces about 50 mg per day, this represents an increase in cortisol activity of about 30% but only about 5% increase in cortisol levels. A nice trade-off I’d say! The beauty part of this is that someone with an autoimmune disease can get increased cortsiol ACTIVITY without actually increasing the cortisol level to the point that it would stimulate feedback to the adrenal gland and lower one’s own production of cortisol. Cortisol acts like a break on the immune system and is the hormone of choice for lowering the hyper immune condition in most autoimmune diseases. The big problem in using regular doses of hydrocortisone (cortisol) sends feedback to the adrenals and one’s own production is reduced accordingly. Shut down the adrenal gland and it is unlikely that it will recover previous preformance. That’s why using hydrocortisol in large doses is so dangerous. Good luck Dave Williams
Response:
KCD wrote: > On Fri, 22 May 1998 10:37:30 -0500, "D. Williams" > <david…@ix.netcom.com> wrote: > >Licorice extract also is as effective as codiene in relieving a cough. It > >kills virus, bacteria and mycoplasma. It is also a potent cancer preventive > >agent. > >D. Williams > Okay…. trick question…. > Where might one find licorice extract, Dave? > kc
Okay…. trick answer….. I don’t know!
Response:
On Fri, 22 May 1998 10:37:30 -0500, "D. Williams" <david…@ix.netcom.com> wrote: >Licorice extract also is as effective as codiene in relieving a cough. It >kills virus, bacteria and mycoplasma. It is also a potent cancer preventive >agent. >D. Williams
Okay…. trick question…. Where might one find licorice extract, Dave? kc
Response:
Where do you find this purer form of licorice?
Response:
I had to import it from Greece and Italy. I have extra for sell but please don’t attack me for spam or whatever. All the proceeds from the sell of licorice is donated to charity. I have put togeather a web site for licorice and chronic fatigue syndrome at: http://www.serve.com/licorice The site is designed to help people with chronic fatigue but much of the information will likely apply to lupus. There are no quarantees and I have no experience in helping people with lupus, but the herb is cheap and worth a try since it has so many other benefits, including cancer prevention. Four months trial supply would cost about $10 per month and I would volunteer to help a lupus patient get started for no charge provided the person agreed to help others if they got good response with licorice. Dave Williams – Hide quoted text — Show quoted text -Daniel Richards wrote: > Where do you find this purer form of licorice?
Response:
how much licorice extract should be taken?
Response:
Some rough comments on licorice dosing: In taking licorice extract to treat a certain illness, one must treat and measure results and then adjust dose and treat and measure results, and so on until the right dose is found. Since the major ingredient in licorice, glycyrrhizin, must first be metabolized in the gut by specific bacteria into 18-beta-glycyrrhetinic acid before it becomes bioactive, the dosage will depend more on the condition the patient’s gut flora and the presents of the special glycyrrhizin metabolizing bacteria. One of the main values of licorice extract in autoimmune diseases like lupus seems to be its cortisol increasing activity. Since licorice increases cortisol activity by inhibiting the enzyme that deactivates cortisol, the dosage of licorice needed will naturally depend on the patient’s gut flora and the amount of cortisol deactivating enzyme that each individual produces in his own body. If anyone recommends a set dose of licorice extract without explaining the need to vary dosage, don’t trust them because they do not understand the workings of licorice. Licorice extract dosing is individual determined by experience and experimentation. Seek out someone experienced in the use of this herb for advice. Don’t waste your money on health-food store licorice "root". None of the root we examined was properly label with the glycyrrhizin content clearly marked. Since getting the proper dose of licorice is difficult even if you know the glycyrrhizin content, youy can understand how impossible it would be without knowing. Dave Williams – Hide quoted text — Show quoted text -Daniel Richards wrote: > how much licorice extract should be taken?
Response:
allgreek2u wrote: > i find this interesting ,as my daughter has vitiligo another autoimmune > disease, and i read liquorice cured someone with this too.
Most autoimmune illnesses respond to increasing cortisol. Since licorice extract deactivates the enzyme that breaks down cortisol and thereby increases cortisol activity, there’s no reason to believe that the herb will not benefit many illness. But getting good results from licorice extract is tricky and you must work with someone who knows what they are doing. In my group there are ~500 CFS patients now taking licorice and offering feedback. As far as I know, this is the largest group ever to take the herb and communicte back and forth, giving helpful hints and etc. to each other. Besides the improvement in fatigue, the one other benefit that most have noticed is in the digestive system. Licorice extract seems to do more for the stomach than any product I’ve ever read about, but the effect takes about 3 months to be fully noticed. Licorice extract also is as effective as codiene in relieving a cough. It kills virus, bacteria and mycoplasma. It is also a potent cancer preventive agent. D. Williams
Response:
- Hide quoted text — Show quoted text -D. Williams wrote: > Ian Liberman wrote: > > A report out of Japan said that doctors were able to modulate the immune > > system in mice with licorice therefore putting the mice with lupus in > > remission. Does anyone know anything about this? Ian > Low doses of hydrocortisone (cortisol) has been used successfully to treat > lupus. The problem is that taking extra cortisol feedbacks to the adrenal > gland and down-regulates one’s on production, which could lead to adrenal > gland failure. > Licorice extract contains glycyrrhizin. Glycyrrhizin inhibits 11-beta > hydroxysteriod dehydrogenase, the enzyme that converts cortisol to its > inactive form, cortisone. By inhibiting this enzyme, your own cortisol > activity is increased without actually increasing cortisol levels. In other > words, your cortisol stays bioactive longer by blocking the enzyme that > deactivates cortisol. > Taking low doses of properly labeled licorice extract (glycyrrhizin content > known) can be followed 3 hours later by 2.5 mg of hydrocortisone for an > extra benefit without much danger of feedback to the adrenal. Licorice > requires about 3 hours to reach maximum inhibition of the enzyme that > deactivates cortisol, therefore the low dose of hydrocortisone 3 hours after > taking a controlled licorice dose is potentiated by ~5-6 times and may be of > great benefit to lupus. > Licorice "root" is not the same as licorice "extract." One must also know > the content of glycyrrhizin in the licorice you use. > D. Williams
The question becomes does licorice by itself produce enough cortisone in the body tobe benificial without taking extra? What doses would be effective? Ian
Response:
i find this interesting ,as my daughter has vitiligo another autoimmune disease, and i read liquorice cured someone with this too. KCD <kcdoc…@ghg.net> wrote in article <35615e43.1712…@news.ghgcorp.com>… On Mon, 18 May 1998 08:37:52 -0400, Ian Liberman <i…@idirect.com> wrote: >A report out of Japan said that doctors were able to modulate the immune >system in mice with licorice therefore putting the mice with lupus in >remission. Does anyone know anything about this? Ian
this is different. Hadn’t heard about this. Licorice contains chemicals that are similar to human hormones. They are not the same, but similar. "Phytoestrogens " I believe is what they’re called. I suppose it’s possible that these might have similar effects to DHEA. For this reason, licorice is also believed to be a bit of a stimulant for helping with sexual performance… There is a caveat of course, as with all such things, moderation is important. Excessive amounts of licorice can make you very sick.. (but I do mean *excessive*). and most licorice candy in the U.S. is made from Anise rather than Licorice root. Anise also has similar phytoestrogens but in lesser amount. Also… excessive amount of licorice mean excessive amounts of sugar, fat, etc… at least in the form it is available to most folks. kc
Response:
Ian Liberman wrote: > The question becomes does licorice by itself produce enough cortisol in the > body to be benificial without taking extra hydrocortisone? What doses would be > effective? Ian
Licorice does not produce cortisol in the body, which is why the herb does not signal feedback to the adrenal gland and lower your own production. Rather, licorice extract inhibits the enzyme that deactivates cortisol, thereby allowing your own production to last longer and do more! Weather taking extract alone would be enought to help without adding low dose hydrocortisone is a good question. I guess it would depend on just how sick you are? Licorice alone does not cure chronic fatigue syndrome, but it does relieve many of the symptoms and users report about a 40% improvement will on licorice extract. Adding low doses of hydrocortisone relieves symptoms an additional 30%, but sometimes users report that the addition of hydrocortisone causes some depression. To get around the depression, we recommend that users add hydrocortisone very slowly, starting at > 1 mg per day for several weeks then ramping up by .5 mg every week until reaching 2.5 mg. We also recommend that the hydrocortisone be used in two days on, one day off schedule as a extra measure of precaution against feedback to the adrenal. Licorice and low dose hydrocortisone is a very potent combination and can relieve much suffering if used properly. But you must know exactly what you are taking! Reagular licorice sold off the shelve will not help simply because you do not know the ingredients and can not be sure of what you are taking.
Response:
A report out of Japan said that doctors were able to modulate the immune system in mice with licorice therefore putting the mice with lupus in remission. Does anyone know anything about this? Ian
Response:
On Mon, 18 May 1998 08:37:52 -0400, Ian Liberman <i…@idirect.com> wrote: >A report out of Japan said that doctors were able to modulate the immune >system in mice with licorice therefore putting the mice with lupus in >remission. Does anyone know anything about this? Ian
this is different. Hadn’t heard about this. Licorice contains chemicals that are similar to human hormones. They are not the same, but similar. "Phytoestrogens " I believe is what they’re called. I suppose it’s possible that these might have similar effects to DHEA. For this reason, licorice is also believed to be a bit of a stimulant for helping with sexual performance… There is a caveat of course, as with all such things, moderation is important. Excessive amounts of licorice can make you very sick.. (but I do mean *excessive*). and most licorice candy in the U.S. is made from Anise rather than Licorice root. Anise also has similar phytoestrogens but in lesser amount. Also… excessive amount of licorice mean excessive amounts of sugar, fat, etc… at least in the form it is available to most folks. kc
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I don’t know if it works, but I eat lots of it. Did they say what kind?
Response:
Ian Liberman wrote: > A report out of Japan said that doctors were able to modulate the immune > system in mice with licorice therefore putting the mice with lupus in > remission. Does anyone know anything about this? Ian
Low doses of hydrocortisone (cortisol) has been used successfully to treat lupus. The problem is that taking extra cortisol feedbacks to the adrenal gland and down-regulates one’s on production, which could lead to adrenal gland failure. Licorice extract contains glycyrrhizin. Glycyrrhizin inhibits 11-beta hydroxysteriod dehydrogenase, the enzyme that converts cortisol to its inactive form, cortisone. By inhibiting this enzyme, your own cortisol activity is increased without actually increasing cortisol levels. In other words, your cortisol stays bioactive longer by blocking the enzyme that deactivates cortisol. Taking low doses of properly labeled licorice extract (glycyrrhizin content known) can be followed 3 hours later by 2.5 mg of hydrocortisone for an extra benefit without much danger of feedback to the adrenal. Licorice requires about 3 hours to reach maximum inhibition of the enzyme that deactivates cortisol, therefore the low dose of hydrocortisone 3 hours after taking a controlled licorice dose is potentiated by ~5-6 times and may be of great benefit to lupus. Licorice "root" is not the same as licorice "extract." One must also know the content of glycyrrhizin in the licorice you use. D. Williams
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