Question:
I have had very severe vasculitis in my hands and feet during the 1980 so it involved swelling and pain in my toes and fingers. on the whole it resolved when my lupus was treated at that time prednisolone was the treatment used .It consisted of red painful lumps, which leads to numbness in the feet and hands eventually. It is not pleasant ,but can lead to cerebral involvement which can lead to strokes which did happen in my case , so it should not be taken lightly . Warmest wishes Erina
Response:
Erina, I’m sorry to hear that you have vasculitis. Did I read correctly that you did have a stroke? I feel for you as strokes have run in my father’s family as well as My wife’s family. My wife, Kelley (43), has been battling both SLE and DLE throughout her system since Apr01. It has now turned on to her kidneys, heart and caused vasculitis in her brain among a host of symptoms. Both we and her doctors at Walter Reed are very concerned. We don’t know what her longterm prognosis will be (hopeful, but realistic too), but Kelley gave me a bad scare over the holidays as her kidneys and bowels shut down for several days as a result of severe dehydration due to catching the flu. Unfortunately, I was the culprit that brought it home to her. 10 days at Walter Reed got her up and going again thank God. Neither of us is ready for my to be a single parent of our 3-year old daughter, Kelsey (who is currently staying with my sister for the next 2 months while Kelley recuperates). Kelley finds herself being forced to face this head on now as she was in denial for a long time. It is hard for me as her caregiver as I feel that I’m standing on the sidelines only offering comfort, but it is the best that I can offer. regards, Daniel "Erina" <er…@btinternet.com> wrote in message
news:bu8in2$dq5$1@hercules.btinternet.com… – Hide quoted text — Show quoted text -> I have had very severe vasculitis in my hands and feet during the 1980 so it > involved swelling and pain in my toes and fingers. on the whole it resolved > when my lupus was treated at that time prednisolone was the treatment used > .It consisted of red painful lumps, which leads to numbness in the feet and > hands eventually. > It is not pleasant ,but can lead to cerebral involvement which can lead to > strokes which did happen in my case , so it should not be taken lightly . > Warmest wishes > Erina
Response:
<Antonso…@comcast.net> wrote in message
: Erina, : I’m sorry to hear that you have vasculitis. Did I read correctly that you : did have a stroke? I feel for you as strokes have run in my father’s family : as well as My wife’s family. : My wife, Kelley (43), has been battling both SLE and DLE throughout her : system since Apr01. It has now turned on to her kidneys, heart and caused : vasculitis in her brain among a host of symptoms. Both we and her doctors : at Walter Reed are very concerned. We don’t know what her longterm : prognosis will be (hopeful, but realistic too) : Kelley finds herself being forced to face this head on now as she was in : denial for a long time. It is hard for me as her caregiver as I feel that : I’m standing on the sidelines only offering comfort, but it is the best that : I can offer. : regards, : Daniel Oh Daniel that is just wonderful ! …. I mean the fact that you can and are offering her comfort and support! That is so much more than alot of the members here have in their court and it says alot about your character as well as the obvious fact that you love her! I wish you both tremendous good luck and an excellent prognosis which finds you both doting on each other in your ‘old age’! <g> Hugs from Shelagh
Response:
Daniel I have survived 22 year since my stroke but I am considerably dis disabled now. I have had to fight my Drs all along the way. Offering comfort is very valuable to the patient. It is the small things that are often appreciated most in life because they show you care and love them, Warmest wishes Erina "Shelagh" <tidering…@shaw.ca> wrote in message
news:c52Ob.137433$ts4.101422@pd7tw3no… – Hide quoted text — Show quoted text -> <Antonso…@comcast.net> wrote in message > : Erina, > : I’m sorry to hear that you have vasculitis. Did I read > correctly that you > : did have a stroke? I feel for you as strokes have run in my > father’s family > : as well as My wife’s family. > : My wife, Kelley (43), has been battling both SLE and DLE > throughout her > : system since Apr01. It has now turned on to her kidneys, heart > and caused > : vasculitis in her brain among a host of symptoms. Both we and > her doctors > : at Walter Reed are very concerned. We don’t know what her > longterm > : prognosis will be (hopeful, but realistic too) > : Kelley finds herself being forced to face this head on now as > she was in > : denial for a long time. It is hard for me as her caregiver as > I feel that > : I’m standing on the sidelines only offering comfort, but it is > the best that > : I can offer. > : regards, > : Daniel > Oh Daniel that is just wonderful ! > …. I mean the fact that you can and are offering her comfort > and support! > That is so much more than alot of the members here have in their > court and it says alot about your character as well as the > obvious fact that you love her! > I wish you both tremendous good luck and an excellent prognosis > which finds you both doting on each other in your ‘old age’! <g> > Hugs from Shelagh
Response:
Hi Daniel, I was glad to see you back here again. I am so sorry to hear that Kelley has had such a bad time. It sounds best that Kelsey be with her auntie for a while. There is no way either of you could handle looking after her right now. The focus has to be on Kelley’s recovery. I don’t know what to say, really. Things can turn around suddenly and Kelley could find herself doing much better. Even so, she will have an uphill climb. I know how long it can take to come back from a lengthy flare. I am glad that she has you for support. I hope you have someone with whom you can share your emotions. All this is hard on the caregiver too. We are here, whenever you need to talk. I wish you and your family all the best. I will keep you in my thoughts. BJ-Sk. Canada <Antonso…@comcast.net> wrote in message
news:iZqdndL074QGPpXd4p2dnA@comcast.com… – Hide quoted text — Show quoted text -> Erina, > I’m sorry to hear that you have vasculitis. Did I read correctly that you > did have a stroke? I feel for you as strokes have run in my father’s family > as well as My wife’s family. > My wife, Kelley (43), has been battling both SLE and DLE throughout her > system since Apr01. It has now turned on to her kidneys, heart and caused > vasculitis in her brain among a host of symptoms. Both we and her doctors > at Walter Reed are very concerned. We don’t know what her longterm > prognosis will be (hopeful, but realistic too), but Kelley gave me a bad > scare over the holidays as her kidneys and bowels shut down for several days > as a result of severe dehydration due to catching the flu. Unfortunately, I > was the culprit that brought it home to her. 10 days at Walter Reed got her > up and going again thank God. Neither of us is ready for my to be a single > parent of our 3-year old daughter, Kelsey (who is currently staying with my > sister for the next 2 months while Kelley recuperates). > Kelley finds herself being forced to face this head on now as she was in > denial for a long time. It is hard for me as her caregiver as I feel that > I’m standing on the sidelines only offering comfort, but it is the best that > I can offer. > regards, > Daniel > "Erina" <er…@btinternet.com> wrote in message > news:bu8in2$dq5$1@hercules.btinternet.com… > > I have had very severe vasculitis in my hands and feet during the 1980 so > it > > involved swelling and pain in my toes and fingers. on the whole it > resolved > > when my lupus was treated at that time prednisolone was the treatment used > > .It consisted of red painful lumps, which leads to numbness in the feet > and > > hands eventually. > > It is not pleasant ,but can lead to cerebral involvement which can lead > to > > strokes which did happen in my case , so it should not be taken lightly . > > Warmest wishes > > Erina
Response:
>Subject: Re: Vasculitis >From: "Erina" er…@btinternet.com >Date: 1/27/2004 3:21 AM Mountain Standard Time >Message-id: <bv5e33$53…@sparta.btinternet.com> >Doe, I am treated at St. Georges hospital now but by Dr. Axford , the >rheumatologist and immunologist. I also trained there years ago >Warm wishes >Erina
Seems to me the name Oliveira DB rings a bell ..? Is she the same person who ‘rang the alarm’ as to the persecution she encountered when she ’stepped up’ and attempted to ‘discuss’ the problems she found with the trials of the iron binder / chelator desferrioxamine .. ? She is heavily into the iron studies and she might not be adverse to attempting to understand the implications of too much iron in the body .. which leads to a depletion of ‘anti’oxidants. Vasculitis has been recently SHOWN to be implicated in the SAME syndrome .. iron overload. **For the first time, we present one patient with vasculitis of the central nervous system associated with systemic hemochromatosis in superficial siderosis. Therapeutic approach included immunosuppressive therapy and venupunctures in the patient with vasculitis and hemochromatosis, and symptomatic treatment with chelating agents and antioxidants. The patient remained clinically stable for the follow-up period of up to 2 years. CONCLUSIONS: Our case underlines the pathogenetic heterogeneity of superficial siderosis and favors the early diagnosis for prompt initiation of therapy. Besides treatment of the underlying condition, antioxidants and radical scavengers may be effective in halting the progression of the disease** Acta Neurol Scand. 2003 Jan;107(1):54-61. Related Articles, Links Superficial siderosis of the central nervous system: pathogenetic heterogeneity and therapeutic approaches. Leussink VI, Flachenecker P, Brechtelsbauer D, Bendszus M, Sliwka U, Gold R, Becker G. Department of Neurology, University of Wurzburg, Germany. verena.leuss…@mail.uni-weurzburg.de OBJECTIVE: Superficial siderosis of the central nervous system (CNS) is a rare chronic progressive disorder caused by chronic subarachnoid hemorrhage. We present four patients with superficial siderosis of the CNS to describe the characteristic symptoms, and to discuss the pathogenetic heterogeneity and possible new therapeutic approaches. RESULTS: The causes of chronic subarachnoid bleeding in superficial siderosis were different. In two patients surgical treatment of ependymoma or cerebral cavernomas were the underlying diseases. No cause was detected in one patient. For the first time, we present one patient with vasculitis of the central nervous system associated with systemic hemochromatosis in superficial siderosis. Therapeutic approaches included exstirpation of cavernomas as the source of chronic bleeding in one patient, immunosuppressive therapy and venupunctures in the patient with vasculitis and hemochromatosis, and symptomatic treatment with chelating agents and antioxidants. The patients remained clinically stable for the follow-up period of up to 2 years. CONCLUSIONS: Our cases underline the pathogenetic heterogeneity of superficial siderosis and favor the early diagnosis for prompt initiation of therapy. Besides treatment of the underlying condition, antioxidants and radical scavengers may be effective in halting the progression of the disease. PMID: 12542514 [PubMed - indexed for MEDLINE] ————————————————————————– —— – Hide quoted text — Show quoted text ->"doe" <ironjust…@aol.comdoe> wrote in message >news:20040126112217.12748.00000855@mb-m29.aol.com… >> >Subject: Vasculitis >> Int Immunol. 2002 Mar; 14(3): 267-73. Related Articles, Links >> Antioxidants inhibit mercuric chloride-induced early vasculitis. >> Wu Z, Turner DR, Oliveira DB. >> Division of Renal Medicine, St George’s Hospital Medical School, Cranmer >> Terrace, London SW17 0RE, UK. z…@sghms.ac.uk >> PMID: 11867563 [PubMed - indexed for MEDLINE] >> ————————————————————————–
Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Response:
While vasculitis secondary to some primary autoimmune disease such as lupus may respond to prednisolone alone, primary autoimmune vasculitides do not all go into remission on a corticosteroid alone. A number of the primary autoimmune vasculitides require more aggressive treatment. Bruce
Response:
>Subject: Vasculitis
Int Immunol. 2002 Mar; 14(3): 267-73. Related Articles, Links Antioxidants inhibit mercuric chloride-induced early vasculitis. Wu Z, Turner DR, Oliveira DB. Division of Renal Medicine, St George’s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. z…@sghms.ac.uk In the Brown Norway (BN) rat, mercuric chloride (HgCl(2)) induces a T(h)2-dominated autoimmune syndrome which includes an early phase of mast cell-dependent vasculitis. We have shown in vitro that oxidative stress up-regulates IL-4 in mast cells and predisposes to degranulation. The aim of this study was to determine whether administration of antioxidants inhibits HgCl(2)-induced early vasculitis in vivo, and, if so, to examine whether modulation of the oxidative/antioxidative balance influences IgE and IL-4 expression by mast cells in situ. Groups of rats were given HgCl(2) + saline, HgCl(2) + N-acetyl-L-cysteine (NAC), saline + saline or saline + NAC respectively and blood was taken and animals killed 48 h later. NAC significantly reduced both HgCl2-induced early vasculitis and HgCl(2)-enhanced IgE expression on mast cells with a trend to a decrease in HgCl(2)-enhanced IL-4 expression in these cells. In addition, there was an increased rat mast cell protease (RMCP) II concentration in the serum after HgCl(2) injection and the elevated levels of RMCP II stimulated by HgCl(2) were totally abolished by the administration NAC in the HgCl(2) + NAC group. However, there was no significant change in serum total IgE concentrations between the HgCl(2) + saline group and the HgCl(2) + NAC group. The non-sulphydryl-containing antioxidants desferrioxamine and pyruvate demonstrated a similar effect in inhibiting HgCl(2)-induced early vasculitis. Our data show that administration of an antioxidant to BN rats reduces HgCl(2)-induced early vasculitis, suggesting that oxidative stress plays a role in the pathogenesis of HgCl(2)-induced early vasculitis. This finding may have implications for the understanding of the initiation in this experimental model of T(h)2 cell-driven autoimmunity and possibly of analogous human diseases. PMID: 11867563 [PubMed - indexed for MEDLINE] ————————————————————————– —— Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Response:
Doe, I am treated at St. Georges hospital now but by Dr. Axford , the rheumatologist and immunologist. I also trained there years ago Warm wishes Erina "doe" <ironjust…@aol.comdoe> wrote in message
news:20040126112217.12748.00000855@mb-m29.aol.com… – Hide quoted text — Show quoted text -> >Subject: Vasculitis > Int Immunol. 2002 Mar; 14(3): 267-73. Related Articles, Links > Antioxidants inhibit mercuric chloride-induced early vasculitis. > Wu Z, Turner DR, Oliveira DB. > Division of Renal Medicine, St George’s Hospital Medical School, Cranmer > Terrace, London SW17 0RE, UK. z…@sghms.ac.uk > In the Brown Norway (BN) rat, mercuric chloride (HgCl(2)) induces a > T(h)2-dominated autoimmune syndrome which includes an early phase of mast > cell-dependent vasculitis. We have shown in vitro that oxidative stress > up-regulates IL-4 in mast cells and predisposes to degranulation. The aim of > this study was to determine whether administration of antioxidants inhibits > HgCl(2)-induced early vasculitis in vivo, and, if so, to examine whether > modulation of the oxidative/antioxidative balance influences IgE and IL-4 > expression by mast cells in situ. Groups of rats were given HgCl(2) + saline, > HgCl(2) + N-acetyl-L-cysteine (NAC), saline + saline or saline + NAC > respectively and blood was taken and animals killed 48 h later. NAC > significantly reduced both HgCl2-induced early vasculitis and HgCl(2)-enhanced > IgE expression on mast cells with a trend to a decrease in HgCl(2)-enhanced > IL-4 expression in these cells. In addition, there was an increased rat mast > cell protease (RMCP) II concentration in the serum after HgCl(2) injection and > the elevated levels of RMCP II stimulated by HgCl(2) were totally abolished by > the administration NAC in the HgCl(2) + NAC group. However, there was no > significant change in serum total IgE concentrations between the HgCl(2) + > saline group and the HgCl(2) + NAC group. The non-sulphydryl-containing > antioxidants desferrioxamine and pyruvate demonstrated a similar effect in > inhibiting HgCl(2)-induced early vasculitis. Our data show that administration > of an antioxidant to BN rats reduces HgCl(2)-induced early vasculitis, > suggesting that oxidative stress plays a role in the pathogenesis of > HgCl(2)-induced early vasculitis. This finding may have implications for the > understanding of the initiation in this experimental model of T(h)2 cell-driven > autoimmunity and possibly of analogous human diseases. > PMID: 11867563 [PubMed - indexed for MEDLINE] > ————————————————————————– > —— > Who loves ya. > Tom > Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com > Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore > DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking – Hide quoted text — Show quoted text –
Response:
Hello friends! Could someone please explain what this disease is(Vasculitis) andor post links that would help me to find out. TIA Hugs, Susan
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To learn about vasculitis, try these urls: http://vasculitis.med.jhu.edu/ http://www.blackandwhite.org/savvy/vascu.html http://www.medscape.com/2906.rhtml —
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Vasculitis is inflammation of the blood vessels, and such inflammation can lead to features detectable in the skin. Cutaneous vasculits needs agressive treatment. These lesions often appear as red or black dots or hard spots and are painful. If untreated cutaneous vasculitis can result in breakdown of the skin. Do you have The Lupus book By Dr Daniel Wallace..I suggest if not then you get it. It has been a great help to me. A whole section on vasculits in it. Get both books the Revised Edition too… You can maybe get it in the library. But I suggest you buy it. I did on line at Amazon.com and it was cheaper. Sent it right to me in 2 days… Also you may want to go to theses sites. KCat http://www.ghg.net/schwerpt/mypage.htm http://www.ghg.net/schwerpt/aslfaq20.htm . Lupus Foundation of America (Lots of current information and support groups.) http://internet-plaza.net/lupus/ Lupus Around the World (ONE OF MY FAVORITES! Great search function, Ask a Doc, and support groups.) http://www.mtio.com/lupus North East Lupus Group Homepage (Andy Taylor’s Page) (One of the best lupus websites around.) http://www.kitzbuhel.demon.co.uk/lupus/index.htm About.com (Literally tons of information and links on many other topics as well.) http://lupus.about.com/health/lupus/ Hope this helps……Janers
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Thanks Janers, your a very sweet, helpful person!! Hugs, Susan
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I have had vasculitis 3 times. All three times in my toes, and once it also involved my leg. The most painful was the toes. The treatment was prednisone for a week. I had it the first time 25 years ago. Then, in March 2002 I had it again. (This time they diagnosed it, where 25 years ago they were puzzled.)This is when blood tests were done and I was referred to the internist here who specializes in Lupus treatments. Since going on plaquenil, I’ve only had it once more, this past March. If the places on your toes go from red to dark (like blood blisters), then eventually crack open, don’t be alarmed. On Mon, 28 Apr 2003 13:42:33 GMT, "Kimby" <Kimd…@adelphia.net> wrote: – Hide quoted text — Show quoted text ->I wonder if anyone can answer my question about Vasculitis (spelling?). My >Rheumatologist suspects this on my toes and is sending me to a >dermatologists. What on earth is it and what can I do for it ? Any >information you may have would be helpful. Kim
Response:
In article <ddara.5643$hT2.3262…@news2.news.adelphia.net>, Kimby <Kimd…@adelphia.net> wrote >I wonder if anyone can answer my question about Vasculitis (spelling?). My >Rheumatologist suspects this on my toes and is sending me to a >dermatologists. What on earth is it and what can I do for it ? Any >information you may have would be helpful. Kim
Try http://vasculitis.med.jhu.edu/ which is Johns Hopkins Vasculitis Center — Andy [Chair, N E Lupus Group] See http://www.kitzbuhel.demon.co.uk/lupus for more!
Response:
Kim.. vasculitis is not a specific disease, but inflammation of the blood vessels due to infection, trauma, or an autoimmune dysfunction. It’s likely if you have lupus that your vasculitis would be an autoimmune disease. The treatment for most autoimmune vasculitis includes prednisone for an indeterminate time, and very often a strong immunosuppressive such as cytoxan, methotrexate, etc. A new class of drugs, the monoclonal antibodies, are being used successfully to treat some autoimmune diseases, for example, Enbrel, Remicade, Humira, Rituximab, Zenapax, etc. See the info on vasculitis at two medical clinics: Cleveland Clinic Center for Vasculitis http://www.clevelandclinic.org/arthritis/vasculitis/default.htm Johns Hopkins Vasculitis Clinic http://vasculitis.med.jhu.edu/ Autoimmune vasculitis usually requires early and aggressive treatment to minimize long term damage to organs. For a table showing various autoimmune vasculitides, see Section 32, Table 7 of my web page on Wegener’s granulomatosis at pws.chartermi.net/~blader Good luck, Bruce
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I wonder if anyone can answer my question about Vasculitis (spelling?). My Rheumatologist suspects this on my toes and is sending me to a dermatologists. What on earth is it and what can I do for it ? Any information you may have would be helpful. Kim
Response:
vasculitis is inflammation of the blood vessels. "Vasculitis" is a general term for a group of diseases that involve inflammation in blood vessels. Blood vessels of all sizes may be affected, from the largest vessel in the body (the aorta) to the smallest blood vessels in the skin (capillaries). The size of blood vessel affected varies according to the specific type of vasculitis. http://vasculitis.med.jhu.edu/ HTH Nicole "Kimby" <Kimd…@adelphia.net> wrote in message
news:ddara.5643$hT2.3262586@news2.news.adelphia.net… – Hide quoted text — Show quoted text -> I wonder if anyone can answer my question about Vasculitis (spelling?). My > Rheumatologist suspects this on my toes and is sending me to a > dermatologists. What on earth is it and what can I do for it ? Any > information you may have would be helpful. Kim
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